Rasashastra is a branch of Ayurveda which deals with the description of metals, minerals, animal products, poisonous herbs, most precious things like gold, gems etc & their therapeutic usage. Navasadara is one of the rasadravya (Mineral) included in Sadharana rasa group of drugs whose Satva (extract) has its indications in many diseases which are now known as infectious diseases. Hence to validate the fact scientifically, Navasadara satva was extracted and subjected to Antimicrobial study. The results were suggestive that Navasadara Satva is a potent Antimicrobial drug.