The results of health technology assessment and cost-effectiveness analysis for particular different health technologies are relatively well defined in high-income countries, but little is known about these in low- and low-middle-income countries. However, there is a shortage of methodological guidance to adjust cost-effectiveness results from one to another country setting. This research is to compare the cost-effectiveness of a new hospital-based health technology of a low-middle-income country with a high-income country, to find the factors which systematically determine the difference in cost-effectiveness between high- and low-middle-income countries. A combination of primary data methods from population-based registration, administration, hospital-based, patient level data; and secondary data methods from academic and grey literature for the research in multiple fields of demography, epidemiology, clinical practice, patient characteristics, health services and health finance...
