Reactive oxygen species have been implicated in various diseases, but attempts to find efficient antioxidant treatments for such conditions have met with only limited success. This work describes an antioxidant nanoreactor obtained by encapsulating a dual-enzyme mimic in polymeric nanovesicles. As the mimic detoxifies in situ both superoxide radicals and related hydrogen peroxide, the nanoreactor exhibits antioxidant activity in THP-1 cells. Development of this simple, robust antioxidant nanoreactor represents a new direction in efficiently fighting oxidative stress.
