A paired-like homeodomain transcription factor 2 (PITX2) is another new marker in breast carcinoma when hypermethylation at P2 promoter of this gene was noted to be associated with poor prognostic factor. We investigated the expression of PITX2 protein using immunohistochemistry in invasive ductal carcinoma and its association with the established growth receptors such as ER, PR and HER2. As conclusion,PITX2 is another potential prognostic marker in breast carcinoma that able to add significant information to established prognostic factors of ER and PR. The expression of PITX2 together with PR may carry a very good prognosis.
