Methicillin-resistant Staphylococcus aureus (MRSA), one of the major concerns of nosocomial infections, is particularly alarming due to its association with multiple resistance to other antibiotics. The prevalence of MRSA infections varies from 5% to more than 50%, depending on the characteristics and size of the hospitals. This book explores the prevalence and risk factors of MRSA bacteraemia in a teaching hospital. the prevalence was 40.4 (95%CI:31.0, 50.0)The duration of hospitalisation before isolation of MRSA, age of patients, patients on ventilation and had taken antibiotics were the significant risk factors. This book should give useful information to professionals who involved in the management of patients in the hospital particularly the patients with nosocomial infection.