A comprehensive modelling methodology for analysis of the kinetics of non-native protein aggregation based on general population balance model within the Extended Lumry-Eyring framework is presented. The population balance model is formulated in terms of key parameters, describing relative importance of (un)folding and aggregation kinetics of a protein in diffusion-driven conditions. Both the analytical and numerical solution provide a detailed insight on the intrinsic aggregation kinetics via time-dependent evolution of a variety of experimentally measurable quantities.
| Вес: | 501 |
| Ширина упаковки: | 1 |
| Высота упаковки: | 1 |
| Глубина упаковки: | 1 |
| Количество страниц: | 108 |
| Год выпуска: | 2012 |
| Автор на обложке: | Peter Grancic |
| ISBN: | 9783659212031 |
| Язык издания: | Английский |
| Издательство: | LAP Lambert Academic Publishing |