India is currently in the midst of a CAD epidemic that tends to occur early in Indians than in other ethnic groups.The rates appear to be highest in Kerala (despite its highest literacy) where prevalence of CAD is 13% in urban areas & 7% in rural areas. Diabetes Mellitus is an important risk factor for the development of premature atherosclerosis. The increased rate of CAD in patients with Diabetes Mellitus is attributable in part to specific disorders of lipoprotein metabolism. These include disordered metabolism of VLDL and chylomicrons, that may be atherogenic. The dyslipidaemia of diabetes in the postprandial phase is a major determinant of the atherogenicity of LDL, which may account for the up to 5-fold increase in atherosclerosis in the diabetic patient. Elevated postprandial triglycerides, peak post prandial triglyceridaemia have been associated in clinical trials with both early coronary artery and carotid artery atherosclerosis for persons with hyperlipidaemia...
